Science and Technology cooperation Exploration: Global Science and Technology Project (Phase 3)

In the rapidly developing field of science and technology, innovative projects are constantly emerging. In recent years, there have been significant opportunities in all aspects surrounding cutting-edge technology. International cooperation in science and technology is of great significance in jointly solving global problems, accelerating scientific and technological progress, promoting economic development, promoting personnel training and exchanges, and building a scientific and technological community. The PAI community is committed to building a bridge of scientific and technological exchange, solving common challenges, promoting international cooperation and development, and promoting world peace and prosperity.

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* Source: China International Scienceand Technology Cooperation http://www.cistc.gov.cn/

01 / Use microwave energy to improve the driving range of electric vehicles

Project summary:

The University of Birmingham, located in the UK's second largest city, is a research-led public university and a member of the Russell Group, the Midlands Innovation Alliance, the Global Alliance of Universities and Universities and Universitas 21. Eleven of its alumni and faculty members have won Nobel Prizes. The use of climate control systems in electric vehicles consumes a lot of electricity, resulting in a reduction in driving range of up to 40%. Professor Yongliang Li from the University of Birmingham's School of Chemical Engineering has developed an innovative energy storage system that uses microwave energy to improve the driving range of electric vehicles in extreme weather. The technology, developed in zero-carbon future technology research, is capable of heating or cooling on demand by combining a chemical heat pump with microwave energy, with a much higher energy density than batteries. This system, known as the electronic heat reservoir, is the secondary energy source for electric vehicles. The technology can be used at electric vehicle charging stations to split solid-steam working pairs by microwave energy, condense the steam into a liquid to "charge", and store the microwave energy in an electronic heat bank inside the car. Predictions show that the electronic heat bank will provide efficient cabin temperature control at a lower cost, extending the range by up to 70%, which is more economical than increasing battery capacity. The project is currently in the laboratory stage and University of Birmingham Enterprise has filed a patent application and is looking for commercial partners to license or co-develop the technology.

02 / Steel emission reduction scheme for CO2 separation using double clad SPAR material

Project summary:

Professor Ding Yulong's team at the University of Birmingham used double-clad SPAR materials for carbon dioxide separation to achieve a closed-loop carbon cycle in the process. The technology, currently at the leading international level, was patented in January 2023 and is suitable for renovation and new construction projects. Its unique features are: no key materials, non-toxic, environmental protection, scrap materials can be completely recycled; Mild operating conditions of 700-800 degrees Celsius; 100% selectivity and > 10% primary conversion rate; Low cost and low energy consumption; The current TRL is 3-4.

03 / New generation of C4C concrete technology

Project summary:

The first-generation C4C concrete technology developed by Professor Ding Yulong's team at the University of Birmingham has the following advantages: 1. Up to 5% carbon dioxide can be stored through the carrier, increasing the strength of concrete by 25% and reducing the amount of cement by 20%; 2. The carrier material (adsorbent) is 1-2% of the quality of concrete (admixture); 3. No carbon dioxide leakage during carrier storage or after concrete removal; 4. Can store the carbon dioxide released in the cement production process; 5. Without changing the cement or concrete production process, it can be directly added to the existing concrete technology.

04 / Kingdom of the Unicorns: British Pathfinder Award

Project summary:

The UK's Department for Business and Trade's mission in China includes negotiating trade policy and providing outward-looking trade diplomacy strategies to promote trade between the UK and China and to help British businesses succeed in the global economy. We also provide professional, authoritative and personalised services to help Chinese companies to do business and expand in the UK and make high-quality investments in the UK economy. Launched by the UK Department of Business and Trade, the "Unicorn Kingdom: UK Science and Innovation Pathfinder Award" (hereinafter referred to as the "Pathfinder Award") is officially open to applications from global growth enterprises (Scale-up), including China. The award program recognizes technology growth companies that provide advanced and innovative solutions to real problems. The Pathfinder Awards build on the success of the UK Tech Rocket Awards and are the first global technology awards launched by the UK Department for Business and Trade. The award is open to applications from growth companies in four areas: artificial intelligence, connected autonomous mobility technology, cybersecurity and digital trade solutions. The evaluation is divided into three rounds, and each applicant can only declare one category. The British Department of Business and Trade will strictly screen the applicant enterprises that meet the criteria according to the declaration materials. The shortlisted Chinese enterprises will compete in the final, semi-final and final rounds of the China region. The winner of the semi-final from China will travel to the UK to compete with other finalists from all over the world for the final overall title. The award provides a platform for Chinese technology companies to showcase their innovation and potential for future cooperation with high-tech companies in the UK's more internationally competitive technology sectors.

05 / Dynamin-II inhibitors for tumor immunotherapy

Project summary:

Tumor immunotherapy is a treatment method that restores the normal anti-tumor immune response of the body by restarting and maintaining the tumor-immune cycle, so as to control or eliminate cancer cells without damaging other cells in the body. The main principle is to use the high affinity of monoclonal antibodies to specific antigens/receptors on the surface of tumor cells. But because the receptor is usually inside the cell rather than on the surface, this therapy varies widely from individual to individual and has low overall efficacy. The CMRI team built a library of drugs to inhibit a key protein responsible for the internalization of certain receptors -Dynamin II - allowing a large number of desired receptors to separate and aggregate on the cell surface, making it susceptible to antibody therapy. The research team has confirmed through animal experiments that the antipsychotic drug procloprazine, which has been on the market for many years, has a high potency to inhibit the off-target effect of Dynamin II. The team is currently conducting a Phase I trial in 10 patients using prochlorrazine (an antihistamine) as an adjunct to cetuximab (an antibody targeting EGFR). Multiple solid tumor samples including triple-negative breast cancer, head and neck squamous cell carcinoma, and adrenal cortical carcinoma were recruited to collect more data on prochlorrazine as a potent inhibitor of Dynamin II.

Prochlorazine has been in clinical use for more than 30 years, and new formulations based on prochlorazine have high market acceptance.

Foreign parties seek investors or partners for preclinical and clinical development of Dynamin II inhibitor candidates.